In 1996, four biologists Kasianowicz, Brandin, Branton and Deamer posed an interesting physics question: can we sequence a DNA without DNA polymerase, by only using a nanopore and electrical current?  Nearly two decades later, we now understand the limit set by the Second Law of thermodynamics and how one may accomplish this grand goal. It turns out, a key part of the answer was already in Erwin Schrodinger's other equation in 1915.