Optical tomography is an ill-posed problem in theory. A priori information, precise forward solution, and sophisticated reconstruction techniques can improve the reconstruction quality of optical tomography. Multimodal optical tomography is being developed to provide rich imaging information for biological research as  well as benefiting optical tomography. In this talk, we will discuss the developed dual- and tri-modal multimodal optical imaging system and demonstrate current progress in forward and inverse problem of optical tomography.